Detailed view for TGME49_215940

Basic information

TDR Targets ID: 260721
Toxoplasma gondii, Acetyl-coenzyme A transporter, putative
Source Database / ID:  ToxoDB 

pI: 5.5183 | Length (AA): 605 | MW (Da): 65464 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13000   Acetyl-coenzyme A transporter 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0008521   acetyl-CoA transporter activity  
GO:0016021   integral to membrane  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
473 507 2wpv (B) 12 46 40.00 0.62 0.19 0.242651 2.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile VEG Tachyzoite, ME49 merozoite. Gregory Hehl AB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Fritz HM Sibley/Greg
Show/Hide expression data references
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_128203)

Species Accession Gene Product
Babesia bovis BBOV_IV007580   acetylCoA transporter, putative
Brugia malayi Bm1_47010   Protein C21B10.09 in chromosome II
Brugia malayi Bm1_00440   Protein C21B10.09 in chromosome II
Candida albicans CaO19.3782   acetyl coenzyme A transporter
Candida albicans CaO19.11263   acetyl coenzyme A transporter
Caenorhabditis elegans CELE_T26C5.3   Protein T26C5.3, isoform C
Cryptosporidium hominis Chro.60065   hypothetical protein
Cryptosporidium parvum cgd6_470   hypothetical protein
Dictyostelium discoideum DDB_G0278059   hypothetical protein
Drosophila melanogaster Dmel_CG9706   CG9706 gene product from transcript CG9706-RA
Echinococcus granulosus EgrG_000410500   solute carrier family 33
Echinococcus multilocularis EmuJ_000410500   solute carrier family 33
Homo sapiens ENSG00000169359   solute carrier family 33 (acetyl-CoA transporter), member 1
Loa Loa (eye worm) LOAG_06692   hypothetical protein
Mus musculus ENSMUSG00000027822   solute carrier family 33 (acetyl-CoA transporter), member 1
Neospora caninum NCLIV_060190   acetyl-CoA transporter, putative
Plasmodium berghei PBANKA_0519800   acetyl-CoA transporter, putative
Plasmodium falciparum PF3D7_1036800   acetyl-CoA transporter, putative
Plasmodium knowlesi PKNH_0621300   acetyl-CoA transporter, putative
Plasmodium yoelii PY01010   Drosophila melanogaster SD08430p
Saccharomyces cerevisiae YBR220C   hypothetical protein
Schistosoma japonicum Sjp_0072930   Uncharacterized membrane protein YBR220C, putative
Schistosoma japonicum Sjp_0104420   expressed protein
Schistosoma japonicum Sjp_0002110   Acetyl-coenzyme A transporter 1, putative
Schistosoma japonicum Sjp_0002100   Acetyl-coenzyme A transporter 1, putative
Schistosoma japonicum Sjp_0002080   Acetyl-coenzyme A transporter 1, putative
Schistosoma japonicum Sjp_0203530   ko:K03372 MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA, putative
Schistosoma japonicum Sjp_0095150   Acetyl-coenzyme A transporter 1, putative
Schistosoma mansoni Smp_159740   solute carrier family 33 (acetyl-CoA transporter
Schistosoma mansoni Smp_076950   solute carrier family 33 (acetyl-CoA transporter
Schmidtea mediterranea mk4.000121.11  
Toxoplasma gondii TGME49_215940   Acetyl-coenzyme A transporter, putative
Theileria parva TP03_0258   hypothetical protein

Essentiality

TGME49_215940 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_T26C5.3 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0519800 Plasmodium berghei Slow plasmo
TGME49_215940 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 33 (acetyl-CoA transporter), member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6586 1 1
0.5784 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6083 1 1
0.0073 0.5 0.5
0.6759 1 1
0.0126 1 1
0.6677 1 0.5
0.6084 0.63 1
0.0073 0.5 0.5
0.6499 1 1
0.6726 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.5455 1 0.5
0.0073 0.5 0.5
0.627 1 0.5
0.0073 0.5 0.5
0.5532 1 0.5
0.0073 0.5 0.5
0.5707 0.5702 0.5
0.0073 0.5 0.5
0.6046 1 0.5
0.6499 1 1
0.3824 1 1
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6247 1 0.5
0.0073 0.5 0.5
0.1797 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.646 1 0.5
0.0073 0.5 0.5
0.6084 0.63 1
0.0073 0.5 0.5
0.2066 1 1
0.5707 0.5702 0.5
0.0073 0.5 0.5
0.6409 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6662 1 0.5
0.6499 1 1
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6181 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6757 1 1
0.0073 0.5 0.5
0.5707 0.5702 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6642 1 1
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6586 1 1
0.6518 0.4124 1
0.2229 1 0.5
0.2229 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6708 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6759 1 1
0.6084 0.63 1
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6203 1 1
0.0073 0.5 0.5
0.5824 1 1
0.6499 1 1
0.6693 0.5 0.5
0.6203 1 1
0.6586 1 1
0.0073 0.5 0.5
0.6759 1 1
0.0073 0.5 0.5
0.6492 0.3891 1
0.2121 1 1
0.6084 0.63 1
0.0073 0.5 0.5
0.6642 1 1
0.6208 1 0.5
0.6436 1 1
0.632 1 0.5
0.6182 1 0.5
0.0073 0.5 0.5
0.5707 0.5702 0.5
0.0073 0.5 0.5
0.58 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.5455 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6492 0.3891 1
0.6647 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6084 0.63 1
0.6083 1 1
0.6644 1 1
0.5835 1 0.5
0.0073 0.5 0.5
0.0073 0.5 0.5
0.6436 1 1
0.0073 0.5 0.5
0.5849 1 1
0.6499 1 1
0.5903 1 0.5
0.3082 1 1
0.5566 1 1
0.0073 0.5 0.5
0.6084 0.63 1
0.5344 1 0.5
0.6645 1 1
0.6084 0.63 1
0.6318 1 1
0.5566 1 1
0.6586 1 1
0.5413 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_215940 (Toxoplasma gondii), Acetyl-coenzyme A transporter, putative
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